Taxonogenomic Analysis of Marine-Derived Streptomyces sp. N11-50 and the Profile of NRPS and PKS Gene Clusters

Streptomyces sp. N11-50 was isolated from deep-sea water and found to produce diketopiperazine (DKP) compounds such as albonoursin cyclo(Phe-Leu). This study aimed reveal the potential synthesize diverse nonribosomal peptide polyketide other secondary metabolites different DKP after clarifying taxonomic position. Strain identified albus, it showed 100% 16S rRNA gene sequence similarities 95.5% DNA–DNA relatedness S. albus NBRC 13014T. We annotated synthetase (NRPS) synthase (PKS) clusters in genome. Consequently, five NRPS, one hybrid PKS/NRPS, type-I PKS type-II were observed, of which we predicted products through bioinformatic analysis. These well conserved already whole-genome (WGS)-published strains belonging albus. On hand, our taxonogenomic analysis revealed that three WGS-published not Two should be classified albidoflavus, remaining likely a new genomospecies. After reclassifying these appropriately, demonstrated species-specific profiles NRPS with little strain-level diversities.